期刊
MULTIPLE SCLEROSIS JOURNAL
卷 18, 期 7, 页码 1038-1041出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458511428465
关键词
cerebrospinal fluid; multiple sclerosis; natalizumab therapy; oligoclonal bands
资金
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2010/10725-4]
- CNPq (Comissao Nacional de Pesquisa)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
Intrathecal immunoglobulin synthesis in an oligoclonal pattern is the most common immunologic abnormality detected in MS patients. Various treatments, such as immunomodulators and immunosuppressors, have not been found to modify it. Natalizumab hinders migration of encephalitogenic T-cells into the central nervous system (CNS), reducing inflammatory response. Its impact on CSF oligoclonal bands (OCBs) has not been demonstrated. This report describes its effect in four out of six patients with multiple sclerosis after a mean of 10 infusions: the CSF was negative for OCBs at the second lumbar puncture. In conclusion, natalizumab treatment can reduce CSF OCBs to undetectable levels, although the clinical significance of this observation is not yet known.
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