期刊
MULTIPLE SCLEROSIS JOURNAL
卷 15, 期 2, 页码 262-265出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458508097923
关键词
angiotensin-converting enzyme; cerebrospinal fluid; multiple sclerosis; renin-angiotensin system
资金
- Ministry of Health, Labor, and Welfare of Japan
- Ministry of Education, Science, Sports, and Culture of Japan
- Suzuken Memorial Foundation
- Takeda Science Foundation
Background We reported a reduction in the levels of angiotensin II in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS). Objective and methods To clarify the mechanism underlying this reduction, we assayed angiotensin-converting enzyme (ACE) and ACE2 concentrations along with angiotensin II concentrations in CSF samples from 20 patients with MS and 17 controls with non-neurological diseases. Results ACE levels were significantly elevated in patients with MS compared with controls (48.42 +/- 4.84 vs 44.71 +/- 3.9 pg/mL), whereas ACE2 levels were significantly reduced (2.56 +/- 0.26 vs 2.78 +/- 0.24 pg/mL), acting toward a normalization of angiotensin II levels. Conclusion These results further indicate an alteration of the intrathecal renin-angiotensin system in patients with MS. Multiple Sclerosis 2009; 15: 262-265. http://msj.sagepub.com
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