期刊
MUCOSAL IMMUNOLOGY
卷 8, 期 1, 页码 29-37出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2014.103
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资金
- Deutsche Forschungsgemeinschaft [PA921/4-1]
- Israel Science Foundation [270/09]
- Human Frontiers Science Program Research Grant
- Bar Ilan University-Sheba medical Center joint research fund
Analysis of the intestinal B-cell system and properties of immunoglobulin A, the main antibody isotype produced in the gut, has dominated the rise of mucosal immunology as a discipline. Seminal work established concepts describing the induction, transport, and function of mucosal antibodies. Still, open questions remain and we lack a comprehensive view of how the various sites and pathways of immunoglobulin A induction are integrated to respond to gut antigens. Next-generation sequencing (NGS) offers a novel approach to study B-cell responses, which might substantially enhance our tool box to answer key questions in the field and to take the next steps toward therapeutic exploitation of the mucosal B-cell system. In this review we discuss the potential, challenges, and emerging solutions for gut B-cell repertoire analysis by NGS.
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