4.6 Review

New targets for mucosal healing and therapy in inflammatory bowel diseases

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Phase I Clinical Trial of Smad7 Knockdown Using Antisense Oligonucleotide in Patients With Active Crohn's Disease

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Anti-Tumor Necrosis Factor-alpha Antibodies Induce Regulatory Macrophages in an Fc Region-Dependent Manner

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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WORLD JOURNAL OF GASTROENTEROLOGY (2011)

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CURRENT PHARMACEUTICAL DESIGN (2010)

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Phosphatidylcholine (Lecithin) and the Mucus Layer: Evidence of Therapeutic Efficacy in Ulcerative Colitis?

Wolfgang Stremmel et al.

DIGESTIVE DISEASES (2010)

Editorial Material Gastroenterology & Hepatology

Predicting the response to infliximab from trough serum levels

Paul Rutgeerts et al.

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Clinical implications of mucosal healing for the management of IBD

Guillaume Pineton de Chambrun et al.

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Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease.

Jean Frederic Colombel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

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Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

Daniel K. Podolsky et al.

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Selective targeting of activated T cells in chronic intestinal inflammation

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Adalimumab Safety in Global Clinical Trials of Patients with Crohn's Disease

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Mucosal Healing Predicts Long-term Outcome of Maintenance Therapy with Infliximab in Crohn's Disease

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CCR6 Regulation of the Actin Cytoskeleton Orchestrates Human Beta Defensin-2-and CCL20-mediated Restitution of Colonic Epithelial Cells

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Geethanjali Pickert et al.

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Hiroshi Seno et al.

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Tocilizumab: An Interleukin-6 Receptor Inhibitor for the Treatment of Rheumatoid Arthritis

Susyn L. Plushner

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Human beta defensin 2 promotes intestinal wound healing in vitro

Jan-Michel Otte et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2008)

Article Immunology

TGF-β1 and Smad7 in the regulation of IBD

G. Monteleone et al.

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Article Gastroenterology & Hepatology

Epithelial restitution and wound healing in inflammatory bowel disease

Andreas Sturm et al.

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Rebecca A. Moyer et al.

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Kathrine Frey Froslie et al.

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Arianna Nenci et al.

NATURE (2007)

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Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial

Jean-Frederic Colombel et al.

GASTROENTEROLOGY (2007)

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Toll-like receptor signaling in intestinal epithelial cells contributes to colonic homoeostasis

Jongdae Lee et al.

CURRENT OPINION IN GASTROENTEROLOGY (2007)

Article Immunology

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

Sophie Hue et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Article Gastroenterology & Hepatology

Antibiotic treatment of Crohn's disease: results of a multicentre, double blind, randomized, placebo-controlled trial with rifaximin

C Prantera et al.

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Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease

KR Herllinger et al.

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Article Gastroenterology & Hepatology

A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease

Henri Braat et al.

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Reduced Paneth cell α-defensins in ileal Crohn's disease

J Wehkamp et al.

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Natalizumab induction and maintenance therapy for Crohn's disease

WJ Sandborn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Medicine, General & Internal

Brief report - Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease

G Van Assche et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Gastroenterology & Hepatology

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

M Fukata et al.

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Article Gastroenterology & Hepatology

Trichuris suis therapy for active ulcerative colitis:: A randomized controlled trial

RW Summers et al.

GASTROENTEROLOGY (2005)

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T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

L Fahlén et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Toll-like receptor 9-induced type IIFN protects mice from experimental colitis

K Katakura et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

Article Gastroenterology & Hepatology

Trichuris suis therapy in Crohn's disease

RW Summers et al.

Article Medicine, Research & Experimental

Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

IJ Fuss et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Gastroenterology & Hepatology

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KM Pickard et al.

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Anti-interleukin-12 antibody for active Crohn's disease

PJ Mannon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Review Biochemistry & Molecular Biology

Mechanisms of TGF-β signaling from cell membrane to the nucleus

YG Shi et al.

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CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

I Tiede et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

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MF Neurath et al.

NATURE MEDICINE (2002)

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Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

SB Hanauer et al.

LANCET (2002)

Article Gastroenterology & Hepatology

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis

D Rachmilewitz et al.

GASTROENTEROLOGY (2002)

Article Gastroenterology & Hepatology

Etanercept for active Crohn's disease: A randomized, double-blind, placebo-controlled trial

WJ Sandborn et al.

GASTROENTEROLOGY (2001)

Article Medicine, General & Internal

A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease

BG Feagan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)