期刊
MUCOSAL IMMUNOLOGY
卷 5, 期 6, 页码 691-701出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2012.42
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资金
- NIH [21-AI079533, R01-HL43573]
In a biphasic, ovalbumin (OVA)-induced murine asthma model where allergic airway disease is followed by resolution and the development of local inhalational tolerance (LIT), transforming growth factor (TGF)-beta-expressing CD5(+) B cells were selectively expanded locally in hilar lymph nodes (HLN) of LIT mice. LIT HLN CD5(+) B cells, but not LIT HLN CD5(-)B cells, induced expression of Foxp3 in CD4(+)CD25(-)T cells in vitro. These CD5+ regulatory B cells (Breg) and CD4(+)Foxp3(+) T cells demonstrated similar increases in expression of chemokine receptors (CXCR4 and CXCR5) and co-localized in HLN B cell zones of LIT mice. The adoptive transfer of LIT HLN CD5+ B cells, but not LIT HLN BCD5-B cells, increased the number of CD4(+)Foxp3(+) T cells in the lung and inhibited airway eosinophilia in this OVA model. Thus, Breg in HLNs of LIT mice reside in a CD5(+) TGF-beta-producing subpopulation and co-localize with CD4(+)Foxp3(+) T cells.
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