期刊
MUCOSAL IMMUNOLOGY
卷 5, 期 2, 页码 150-160出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2011.61
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资金
- Swedish Medical Research Council
- Wellcome Trust
- Crafoordska foundation
- Torsten and Ragnar Soderbergs foundation
- Kocks foundation
- Osterlund foundation
- Richard and Ruth Julins foundation
- Royal Physiographic Society
- Swedish foundation for Strategic Research [FFL-2]
- Deutsche Forschungsgemeinschaft [SE 1874/1-1]
The alpha E integrin chain CD103 identifies a subset of migratory dendritic cells (DCs) in the gut, lung, and skin. To gain further understanding of the function of CD103(+) DCs in regulating adaptive immunity in vivo, we coupled ovalbumin (OVA) to the CD103 antibody M290 (M290. OVA). Intraperitoneal injection of M290. OVA induced OVA-specific CD8(+) and CD4(+) T-cell proliferation in lymph nodes (LNs) of wild-type but not CD103(-/-) mice, or in mice depleted of CD11c(+) cells. In the absence of maturation stimuli, systemic antigen targeting to CD103(+) DCs led to tolerance of CD8(+) T cells, whereas coadministration of adjuvant induced cytotoxic T-lymphocyte (CTL) immunity and antibody production. Mucosal intratracheal application of M290. OVA also induced T-cell proliferation in mediastinal LNs, yet the functional outcome was tolerance that inhibited subsequent development of allergic airway inflammation and immunoglobulin E (IgE) responses to inhaled OVA. These findings identify antigen targeting to CD103(+) DCs as a potential strategy to regulate immune responses in nonlymphoid mucosal tissues.
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