期刊
MUCOSAL IMMUNOLOGY
卷 4, 期 2, 页码 139-147出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2010.88
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资金
- Kingston General Hospital
- Queen's University Gastrointestinal Diseases Research Unit
- Physicians' Services Incorporated (PSI) [PAED-237-09]
Eosinophilic esophagitis (EoE) has been increasingly recognized as a unique clinicopathological entity over the past two decades. In this short time, the mechanisms of a complex disease have begun to emerge. Patient studies suggest that EoE is an immunologic disease related to atopy. At the cellular level, eosinophils, mast cells, and B and T lymphocytes are increased in the esophageal mucosa in a patchy distribution throughout the length of the esophagus. Laboratory investigations have implicated aeroallergens, food allergens, and a unique T helper type 2 cytokine profile. EoE appears to be an antigen-driven hypersensitivity reaction characterized by a mixed IgE-dependent/delayed-type reaction and a distinct cascade of cytokines and growth factors. The causative events that lead to EoE in humans remain unknown.
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