Diverse regulatory pathways for IgA synthesis in the gut

Immunoglobulin (Ig) A is the most abundant antibody isotype in mucosal secretions. In this study we summarize recent advances in our understanding of the compartments and mechanisms of intestinal IgA synthesis. We discuss the pathways leading to the generation of IgA(+) B cells in follicular and extra-follicular structures, by T-cell-dependent and T-cell-independent mechanisms.