期刊
MRS BULLETIN
卷 38, 期 4, 页码 326-330出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1557/mrs.2013.60
关键词
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资金
- NIH [1 R01 AI 096184-01]
- DARPA DSO [HR0011-11-2-0007]
- National Science Foundation [DGE-0718124]
The need to improve health outcomes in the developing world and to moderate healthcare costs in developed countries has resulted in an increased interest in sophisticated, inexpensive, and instrument-free point-of-care diagnostics using porous materials. One major segment of the paper-based diagnostics effort is focused on developing high-performance point-of-care tests using porous nitrocellulose membranes. This review provides a perspective on the nature, history, and future of nitrocellulose-based assays. Beginning as a protein blotting substrate, porous nitrocellulose membranes have grown to be the most commonly used lateral flow substrate and are the primary membranes used in two-dimensional paper networks for user-friendly multistep assays. In addition to the historical context, we examine assay development considerations, such as the physics of flow in porous media, reagent deposition and storage, and detection methods.
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