期刊
MRS BULLETIN
卷 35, 期 5, 页码 382-388出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1557/mrs2010.571
关键词
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资金
- Interdisciplinary Research Groups on Infectious Diseases (ID) and BioSystems and Micromechanics (BioSyM)
- Singapore-MIT Alliance for Research and Technology (SMART)
- Singapore-MIT Alliance
- Global Enterprise for Micro-Mechanics and Molecular Medicine (GEM) Laboratory at the National University of Singapore
- National Institute of Health [R01 HL094270-01A1, 1-R01-GM076689-01]
- National University of Singapore
The biconcave shape and corresponding deformability of the human red blood cell (RBC) is an essential feature of its biological function. This feature of RBCs can be critically affected by genetic or acquired pathological conditions. In this review, we highlight new dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics. In particular, recent advances in high-throughput microfluidic devices make it possible to sort/identify healthy and pathological human RBCs with different mechanobiological characteristics.
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