期刊
MOVEMENT DISORDERS
卷 29, 期 6, 页码 819-822出版社
WILEY
DOI: 10.1002/mds.25863
关键词
alcohol; Parkinson's disease; observational study; meta-analysis
资金
- National Natural Science Foundation of China [31371024]
BackgroundThe association of alcohol intake with risk of Parkinson's disease remains unclear. MethodsPertinent studies were identified in PubMed and EMBASE. The fixed-effect or random-effect model was selected based on heterogeneity. The dose-response relationship was assessed by restricted cubic splines. ResultsWe included 32 articles, involving 677,550 subjects (9994 cases). The smoking-adjusted risk of Parkinson's disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67-0.92) overall, 0.86 (95% CI, 0.75-0.995) in prospective studies, and 0.74 (95% CI, 0.58-0.96) in matched case-control studies. A significant association was found with beer (0.59; 95% CI, 0.39-0.90) but not with wine and liquor, and for males (0.65; 95% CI, 0.47-0.90) after a sensitivity analysis but not for females. The risk of Parkinson's disease decreased by 5% (0.95; 95% CI, 0.89-1.02) for every 1 drink/day increment in alcohol intake in a linear (P-for nonlinearity=0.85) dose-response manner. ConclusionsAlcohol intake, especially beer, might be inversely associated with risk of Parkinson's disease (c) 2014 International Parkinson and Movement Disorder Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据