期刊
MOVEMENT DISORDERS
卷 30, 期 2, 页码 266-269出版社
WILEY-BLACKWELL
DOI: 10.1002/mds.26060
关键词
Parkinson's disease; mortality; SMR; cause-specific mortality; late stage
资金
- Austrian science fund (FWF)
- Austrian Science Fund (FWF) [KLI 82] Funding Source: researchfish
BackgroundIn this study we report on the outcome including overall and cause-specific mortality of Parkinson's disease (PD) patients subsequent to 38 years of surveillance. This is an extension study of our previous report on mortality. MethodsTwo hundred thirty-seven patients with a symptom onset between 1974 and 1984 were followed until the date of December 31, 2012 or death, representing a follow-up period of up to 38 years. Overall and cause-specific standardized mortality ratios (SMRs) were calculated, and predictors for survival at disease onset were estimated. Results and ConclusionTwo hundred thirty patients had died by December 31, 2012; a total of 3,489 person-years were available for observation. The SMR at 38 years of follow-up was 2.02 (1.76-2.29). Employing Cox's proportional hazard modeling, male sex, gait disorder, absence of classical rest tremor, and absence of asymmetry predicted poor survival in this cohort. Increased cause-specific SMRs were found for pneumonia and cerebrovascular and cardiovascular diseases. (c) 2014 International Parkinson and Movement Disorder Society
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