期刊
MOVEMENT DISORDERS
卷 28, 期 13, 页码 1847-1853出版社
WILEY
DOI: 10.1002/mds.25653
关键词
REM sleep behavior disorder; gait; gait variability
资金
- NIH, National Institute on Aging (NAI) [U01 AG006786, P50 AG016574, AG015866, R01 AG034676]
- Robert H. and Clarice Smith and Abigail Van Buren Alzheimers Disease Research Program of the Mayo Foundation
- Mangurian Foundation
Many people with rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which is Lewy body disease. Identifying additional abnormal clinical features may help in identifying those at greater risk of evolving to a more severe syndrome. Because gait disorders are common in the synucleinopathies, early abnormalities in gait in those with RBD could help in identifying those at increased risk of developing overt parkinsonism and/or cognitive impairment. We identified 42 probable RBD subjects and 492 controls using the Mayo Sleep Questionnaire and assessed gait velocity, cadence, and stride dynamics with an automated gait analysis system. Cases and controls were similar in age (79.9 +/- 4.7 and 80.1 +/- 4.7, P=0.74), Unified Parkinson's Disease Rating Scale Part III (UPDRS) score (3.3 +/- 5.5 and 1.9 +/- 4.1, P=0.21) and Mini-Mental State Examination scores (27.2 +/- 1.9 and 27.7 +/- 1.6, P=0.10). A diagnosis of probable RBD was associated with decreased velocity (-7.9 cm/s; 95% confidence interval [CI], -13.8 to -2.0; P<0.01), cadence (-4.4 steps/min; 95% CI, -7.6 to -1.3; P<0.01), significantly increased double limb support variability (30%; 95% CI, 6-60; P=0.01), and greater stride time variability (29%; 95% CI, 2-63; P=0.03) and swing time variability (46%; 95% CI, 15-84; P<0.01). Probable RBD is associated with subtle gait changes prior to overt clinical parkinsonism. Diagnosis of probable RBD supplemented by gait analysis may help as a screening tool for disorders of -synuclein. (c) 2013 International Parkinson and Movement Disorder Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据