期刊
MOVEMENT DISORDERS
卷 28, 期 9, 页码 1285-1288出版社
WILEY
DOI: 10.1002/mds.25360
关键词
Parkinson's disease; mild cognitive impairment; transcranial magnetic stimulation; acetylcholine; neurophysiology
资金
- Michael J. Fox Foundation
- Parkinson's UK
- National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust
- Parkinson"
- s UK [J-0802] Funding Source: researchfish
Background Mild cognitive impairment in Parkinson's disease (PD) is common and predicts those at risk of dementia. Cholinergic dysfunction may contribute to its pathophysiology and can be assessed using short latency afferent inhibition. Methods Twenty-two patients with PD (11 cognitively normal; 11 with mild cognitive impairment) and 22 controls participated. Short latency afferent inhibition was measured by conditioning motor evoked potentials, which were elicited by transcranial magnetic stimulation of the motor cortex with electrical stimuli delivered to the contralateral median nerve at varying interstimulus intervals. Results There was no significant difference between cognitively normal PD and controls for short latency afferent inhibition (62.8 +/- 30.3% vs. 55.7 +/- 21.7%; P=0.447). The PD-mild cognitive impairment group had significantly less inhibition (88.4 +/- 25.8%) than both cognitively normal PD (P=0.021) and controls (P=0.01). Conclusions Cholinergic dysfunction occurs early in those with PD-mild cognitive impairment. Short latency afferent inhibition may be a useful biomarker of increased risk of dementia in PD patients. (c) 2013 Movement Disorder Society
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