期刊
MOVEMENT DISORDERS
卷 28, 期 1, 页码 24-30出版社
WILEY
DOI: 10.1002/mds.25032
关键词
Dopamine neuron; inflammation; neurodegeneration; mitochndria; misfolded protein
资金
- National Institutes of Health [NS042269, NS064191, NS38370, NS070276, NS072182]
- U.S. Department of Defense [W81XWH-08-1-0522, W81XWH-08-1-0465, W81XWH-09-1-0245]
- Parkinson Disease Foundation
- Thomas Hartman Foundation For Parkinson's Research
- Wings-over-Wall Street/Muscular Dystrophy Association
- INSERM
- CNRS
- Universite Pierre et Marie Curie
- Cure Parkinson Foundation
- Rosetrees Trust
- Parkinson UK
- National Parkinson Foundation, Centre national de la recherche scientifique, Institut national de la sante et de la recherche medicale
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042269, P50NS038370, RC2NS070276, R21NS072182, R21NS064191] Funding Source: NIH RePORTER
Parkinson's disease is a common adult-onset neurodegenerative disorder whose pathogenesis remains essentially unknown. Currently, it is believed that the neurodegenerative process in Parkinson's disease is a combination of both cell-autonomous and non-cell-autonomous mechanisms. Proposed cell-autonomous mechanisms include alterations in mitochondrial bioenergetics,dysregulation of calcium homeostasis, and impaired turnover of mitochondria. As for the proposed non-cell-autonomous mechanisms, they involve prion-like behavior of misfolded proteins and neuroinflammation. This suggests that cell death in Parkinson's disease is caused by a multifactorial cascade of pathogenic events and argues that effective neuroprotective therapy for Parkinson's disease may have to rely on multiple drug interventions. (C) 2013 Movement Disorder Society
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