期刊
MOVEMENT DISORDERS
卷 26, 期 11, 页码 1976-1984出版社
WILEY
DOI: 10.1002/mds.23821
关键词
Parkinson's disease; pathological gambling; dopamine agonists; impulse control; adverse effects; compulsions
The prevalence of pathological gambling is 3.4% to 6% in treated Parkinson's disease, which is higher than the background population rate. In this review we discuss current evidence to indicate that dopamine agonists are much more likely to trigger this behavior than either L-dopa or selective monoamine oxidase B inhibitor monotherapy. New insights from recent behavioral and functional imaging studies and possible treatment approaches are also covered. A PubMed literature search using the terms gambling and Parkin-son's disease, impulse control disorder, impulsive compulsive behaviour, dopamine agonist, of individual dopamine agonists, and of ongoing drug trials, using http://www.clinicaltrials.gov, was carried out for the period up to January 2011. (C) 2011 Movement Disorder Society
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