期刊
MOVEMENT DISORDERS
卷 25, 期 8, 页码 1012-1018出版社
WILEY
DOI: 10.1002/mds.22993
关键词
Parkinson's disease; rating instrument; freezing; gait disorder
资金
- Deutsche Parkinson Vereinigung e.V.
- Deutsche Stiftung Neurologie e.V.
- Dt. Parkinson Vereinigung e.V.
- Verein fuer Foerderung der Behandlung mid Betreuung neurologisch Kranker e.V.
- Merz Pharmaceuticals
Festination and freezing of gait (FOG) are sudden episodic inabilities to initiate or sustain locomotion mostly experienced during the later stages of Parkinson's disease (PD) or other higher-level gait disorders. The aim of this study was to develop a clinical rating instrument for short-interval rating of festination and FOG. Foot movements of 33 patients were video taped and rated during 12 episodes in a standardized course on a four-level interval scale according to severity. Motor blocks were provoked in four situations and by three levels of dual-tasking (tasks). Addition of the item scores produced a FOG score. The assessment requires less than 15 min. The inter-rater and re-test reliability of the FOG score is high (Kendall kappa = 0.85-0.92, P < 0.0001). Variability of the item scale due to situations and tasks can be attributed to unidimensional group factors (Cronbach's alpha 0.84 and 0.94). Group comparisons and a logistic regression model show significant effects for both situations and tasks on the item scale (Friedman test: situation: P < 0.0001, task: P < 0.0001). Six patients with PD have significantly different scores during mobile (practical ON; 6.2 +/- 3.9) and immobile (practical OFF; 15.8 +/- 4.6) medication states (P < 0.05). The FOG score correlates with the 10 m number of steps (rho = 0.58; P = 0.001) and with the self-evaluation of FOG (rho = 0.51; P < 0.01). Our results encourage the further use of the FOG score to evaluate festination and FOG. (C) 2010 Movement Disorder Society
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