期刊
MOVEMENT DISORDERS
卷 25, 期 7, 页码 932-936出版社
WILEY-LISS
DOI: 10.1002/mds.23070
关键词
uric acid; Parkinson's disease; cross-sectional survey
资金
- C8 Class Action Settlement Agreement (Circuit Court of Wood County, West Virginia)
- Centers for Disease Control and Prevention [PH000018]
- Electric Power Research Institute [EP-P25912/C12525]
- NIOSH [1 R01 OH008989]
- NIH/NIA [P50AG025688]
- Emory Alzheimer's Disease Research Center
- NIH/Fogarty Int'l Center [5D43TW005746]
- NIDDH [5R01DK073217-03]
- American Heart Association [10CRP2600013]
- AHRQ
- West Virginia COHORTS Center [R24-HSO18622]
- West Virginia University
A large community-based cross-sectional survey provided an opportunity to evaluate a previously reported association between Parkinson's disease (PD) and low serum uric acid (UA) levels in this population. The association between a self-reported PD diagnosis with treatment (n = 59) and serum UA level was examined using logistic and linear regression models, controlling for key covariates. In adjusted models, participants with UA levels at or above the median had a significantly lower odds of reporting PD with treatment compared with those with lower UA levels (OR 0.33, 95% CI 0.19-0.60, P = 0.0002). This association was observed for both men and women. The mean UA level among participants reporting PD with treatment was 0.78 mg/dI lower than the mean UA level among those not reporting (D <= 0.0001). These findings concur with several previous longitudinal studies that found an association between higher UA levels and decreased PD risk. (C) 2010 Movement Disorder Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据