期刊
MOVEMENT DISORDERS
卷 25, 期 13, 页码 2239-2246出版社
WILEY
DOI: 10.1002/mds.23222
关键词
cerebellum; cerebellar ataxia; neurorehabilitation; motor control; dynamic balance
资金
- Hertie Institute for Clinical Brain Research
- Volkswagenstiftung
- Hermann and Lilly Schilling Foundation
- Werner Reichardt Centre for Integrative Neuroscience
- Santhera Pharmaceuticals
- Deutsche Forschungsgemeinschaft [SCHO754/4-1, SFB 555, GI305/2]
- German Research Council (BMBF) [01GM0644, 01GM0603, 01GM0864]
- EU [LSHM-CT-2004-503304, FP6-NEST-2005-Path-IMP-043403, SEA-RISE FP7-ICT-215866]
- E-RARE program [01GM0807, 01GM0820]
- HSP-Selbsthilfegruppe Deutschland eV
- Volkswagen Foundation [I/76556-1]
- HFSP-Grant [RGP54/2004]
Few clinical studies have evaluated physiotherapeutic interventions for patients with degenerative cerebellar disease. In particular, evidence for long-term effects and transfer to activities of daily life is rare. We have recently shown that coordinative training leads to short-term improvements in motor performance. To evaluate long-term benefits and translation to real world function, we here assessed motor performance and achievements in activities of daily life 1 year after a 4 week intensive coordinative training, which was followed by a home training program. Effects were assessed by clinical rating scales, a goal attainment score and quantitative movement analysis. Despite gradual decline of motor performance and gradual increase of ataxia symptoms due to progression of disease after 1 year, improvements in motor performance and achievements in activities of daily life persisted. Thus, also in patients with degenerative cerebellar disease, continuous coordinative training leads to long-term improvements, which translate to real world function. (C) 2010 Movement Disorder Society
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