期刊
MOVEMENT DISORDERS
卷 24, 期 2, 页码 224-230出版社
WILEY
DOI: 10.1002/mds.22335
关键词
Parkinson's disease; UPDRS; disease progression
资金
- Morris K Udall Center at the University of Virginia [NIH-NINDS-P50-NS39788]
- American Parkinson Disease Association Advanced Center for Parkinson's Disease Research at UVA
The activities of daily living (ADL) subscore of the Unified Parkinson's Disease Rating Scale (UPDRS) captures file impact of Parkinson's disease (PD) oil daily function and may be less affected than other subsections by variability associated with drug cycle and motor fluctuations. We examined UPDRS mentation, ADL and motor subscores in 888 patients with idiopathic PD. Multiple linear regression analyses determined the association between disease duration and UPDRS subscores as a function of medication status at examination and in a Subset of patients with multiple examinations. Independent of medication status and across cross-sectional and longitudinal analyses, ADL subscores showed a stronger and more stable association with disease duration than other UPDRS subscores after adjusting for age of disease onset. The association between disease duration and file motor subscore depended on medication status. The strong association between ADL subscore and disease duration in PD Suggests that this measure may serve as a better marker of disease progression than signs and symptoms assessed in other UPDRS sections. (C) 2008 Movement Disorder Society
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