期刊
MOVEMENT DISORDERS
卷 24, 期 2, 页码 188-195出版社
WILEY
DOI: 10.1002/mds.22269
关键词
Parkinson's disease; gait initiation; postural instability; magnetic resonance imaging
资金
- Institut National de la Same et de la Recherche Medicale, Pierre et Marie Curie University Paris 6
- Assistance Publique-Hopitaux de Paris
Gait and balance disorders are common in Parkinson's disease (PD), but its pathophysiology is still poorly understood. Step length. antero-posterior, and vertical velocities of the center of gravity (CG) (luring gait initiation were analyzed in 32 controls and 32 PD patients, with and without levodopa, using a force platform. Brain Volumes and mesencephalic Surface area were measured in PD patients. During the swing limb period, controls showed a fall in the CG, which was reversed before foot-contact indicating active braking of the CG fall. In PD patients, without levodopa, step length and velocity were significantly reduced and no braking occurred before Foot-contact in 22 patients. With levodopa, step length and velocity increased in all patients and 7 patients improved their braking capacity. PD patients with normal braking (n = 17) had significantly lower gait and balance disorder scores and higher normalized-mesencephalic surface areas compared to patients with impaired braking (n = 15). The decreased step length and velocity, characteristic of PD, mainly result from degeneration of central dopaminergic systems. The markedly decreased braking capacity observed in half the PD patients contributes to their gait disorders and postural instability, perhaps as a result of nondopaminergic lesions, possibly at the mesencephalic level. (C) 2008 Movement Disorder Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据