期刊
MOVEMENT DISORDERS
卷 24, 期 3, 页码 455-459出版社
WILEY-LISS
DOI: 10.1002/mds.22442
关键词
Parkinson's disease; FGF20; alpha-synuclein; association study; genetics
资金
- Swiss National Science Foundation
- Swiss Parkinson Foundation
- Robert H. and Clarice Smith and the M.L. Simpson Foundation Trust
- Michael J. Fox Foundation
- Morris K. Udall Center of Excellence for Parkinson's Disease Research [P50-NS40256]
- Mayo Clinic ADRC [P50-AG16574]
- Pacific Alzheimer Research Foundation (PARF) [C06-01]
Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels. (C) 2009 Movement Disorder Society
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