期刊
MOVEMENT DISORDERS
卷 24, 期 4, 页码 609-612出版社
WILEY
DOI: 10.1002/mds.22411
关键词
levodopa; sleep; dementia with Lewy bodies
资金
- MRC [G0400074, G0502157] Funding Source: UKRI
- Medical Research Council [G0400074, G0502157] Funding Source: researchfish
- Medical Research Council [G0400074, G0502157] Funding Source: Medline
Sleep disturbance and excessive daytime somnolence (EDS) are features of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) that may be influenced by dopamine replacement therapy. The effect of levodopa on sleep and EDS in DLB is unknown and unclear in PD. The aim of, this study is to determine if levodopa treatment alters sleep symptoms and EDS in DLB. Dopamine naive patients with DLB (n = 15: mean mini mental state examination (MMSE) score 17.7(4.6)) and PD (n = 9; mean MMSE 25.5(2.2)) were assessed using the Epworth sleep scale. Parkinson's disease sleep scale. and the neuropsychiatric inventory prior to initiating treatment with levodopa. All measures were repeated after 3 and 6 months of levodopa therapy. The median final daily levodopa dose was 300 mg in both groups. Baseline sleep measures were comparable between groups. Levodopa treatment did not affect sleep or lead to increased EDS in DLB patients. The use of levodopa does not appear to adversely affect subjective steep measures or increase EDS in DLB patients. (C) 2009 Movement Disorder Society
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