期刊
MOVEMENT DISORDERS
卷 25, 期 1, 页码 108-111出版社
WILEY
DOI: 10.1002/mds.22776
关键词
ataxia; sensory neuron; dysarthria; balance; clinical trial
资金
- Friedreich Ataxia Research Alliance
- National Institutes of Health
- Muscular Dystrophy Association
Dysarthria is Friedreich Ataxia (FA) is difficult to quantify. This study evaluated a series of performance measures for speech in 22 patients with genetically confirmed FA and 16 age-matched controls. Tests included file PATA examination, the PATAKA examination, the Oral Motor component of the Boston Aphasia examination, the Boston Cookie Theft description task. and the Assessment of Intelligibility of Dysarthric Speech. All measures, except the Cookie theft description task. demonstrated significantly lower scores for patients with FA when compared with controls mid correlated with measures of disease progression. Thus, four of five measures capture speech dysfunction in FA and may provide feasible, inexpensive, quantitative testing for therapeutic monitoring in FA. (C) 2009 Movement Disorder Society
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