期刊
MOVEMENT DISORDERS
卷 24, 期 3, 页码 371-376出版社
WILEY
DOI: 10.1002/mds.22360
关键词
Parkinson's disease; constipation; Lewy body; substantia nigra; neuron density
资金
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke [1 RO1 NS412265]
- National Institute on Aging [1 U01 AG19349, 5 R01 AG017155]
- Veterans Affair, Pacific Island Health Care System, Honolulu, Hawaii
- Japan Society for the Promotion of Science
- NIA
Constipation is associated with future risk of Parkinson's disease (PD) and with incidental Lewy bodies (LB) in the locus ceruleus or substantia nigra (SN). Our purpose is to examine the independent association between bowel movement frequency in late-life and postmortem SN neuron density. Bowel movement frequency Was assessed in the Honolulu-Asia Aging Study from 1991 to 1993 in 414 men aged 71 to 93 years with later postmortem evaluations. Brains were examined for LB in the SN and locus ceruleus and neurons Were Mulled in four quadrants from a transverse section of SN. In nonsmokers, neuron densities (counts/mm(2)) for men with >1, 1, and <1 bowel movement daily were 18.5, 18.8, 10.1 (P < 0.001) for dorsomedial: 15.3, 16.4, 10.2 (P < 0.03) for ventromedial; and 18.6, 18.3, 10.9 (P = 0.011) for ventrolateral quadrants. Relationships were not significant in the dorsolateral quadrant or in any quadrant among smokers. After adjustment for age, time to death, coffee drinking, tricep skinfold thickness, excessive daytime sleepiness, cognitive function, PD, and incidental LB, density ratios in nonsmokers with I or more bowel movement(s) daily were significantly higher compared to those with <1 daily. Constipation is associated with low SN neuron density independent of the presence of LB. (C) 2008 Movement Disorder Society
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