期刊
MOVEMENT DISORDERS
卷 23, 期 4, 页码 524-530出版社
WILEY
DOI: 10.1002/mds.21777
关键词
mild parkinsonian signs; olfaction; elderly; population; epidemiology
资金
- NCRR NIH HHS [RR00645, M01 RR000645] Funding Source: Medline
- NIA NIH HHS [P01 AG007232-160010, P01 AG007232, P01 AG007232-170010, P01 AG07232, P01 AG007232-200010, P01 AG007232-190010, P01 AG007232-180010] Funding Source: Medline
- NINDS NIH HHS [R01 NS042859-03, R01 NS042859-01A2, R01 NS042859-05, R01 NS042859-02, R01 NS042859, R01 NS42859, R01 NS042859-04] Funding Source: Medline
Mild Parkinsonian signs (NIPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction Occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community-dwelling elderly with versus without MPS. Nondemented persons age >= 65 years without PD in Washington Heights-Inwood. Ny were evaluated with an abbreviated motor Unified PD Rating Scale and a 40-item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT 41]) indicated greater olfactory dysfunction. One-hundred-seventy-seven (16.4%) of 1,078 participants had NIPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 +/- 7.1 versus 26.4 +/- 6.8. P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04-1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having NIPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across NIPS subtypes (axial dysfunction, rigidity, tremor). MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies. (C) 2007 Movement Disorder Society.
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