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Cell therapy for Parkinson's disease: Only young onset patients allowed? Reflections about the results of recent clinical trials with cell therapy and the progression of Parkinson's disease
Gurutz Linazasoro
CELL TRANSPLANTATION (2006)
Dyskinesias and dopamine cell replacement in Parkinson's disease: a clinical perspective
P Hagell et al.
BRAIN RESEARCH BULLETIN (2005)
Factors affecting the clinical outcome after neural transplantation in Parkinson's disease
P Piccini et al.
BRAIN (2005)
Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model
E Dowd et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
Regenerative medicine in Parkinson's disease: generation of mesencephalic dopaminergic cells from embryonic stem cells
H Taylor et al.
CURRENT OPINION IN BIOTECHNOLOGY (2005)
Does levodopa slow or hasten the rate of progression of Parkinson's disease?
S Fahn
JOURNAL OF NEUROLOGY (2005)
Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified neurturin construct
L Fjord-Larsen et al.
EXPERIMENTAL NEUROLOGY (2005)
Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (Cyno-1) after transplantation
R Sánchez-Pernaute et al.
STEM CELLS (2005)
Regulatable gene expression systems for gene therapy applications: Progress and future challenges
S Goverdhana et al.
MOLECULAR THERAPY (2005)
Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor
YH Ahn et al.
BRAIN RESEARCH BULLETIN (2005)
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections
L Thompson et al.
JOURNAL OF NEUROSCIENCE (2005)
Factors involved in the determination of the neurotransmitter phenotype of developing neurons of the CNS: Applications in cell replacement treatment for Parkinson's disease
SS Riaz et al.
PROGRESS IN NEUROBIOLOGY (2005)
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease
I Mendez et al.
BRAIN (2005)
Immune responses to adeno-associated virus vectors
AK Zaiss et al.
CURRENT GENE THERAPY (2005)
Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production
A Sajadi et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors
T Carlsson et al.
BRAIN (2005)
Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
JT Slevin et al.
JOURNAL OF NEUROSURGERY (2005)
Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: A two-year outcome study
NK Patel et al.
ANNALS OF NEUROLOGY (2005)
The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons
S Chung et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2005)
Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease
A Eslamboli et al.
JOURNAL OF NEUROSCIENCE (2005)
Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: A return to control measures
KB Bjugstad et al.
CELL TRANSPLANTATION (2005)
Neuroprotection in a rat Parkinson model by GDNF gene therapy using EIAV vector
M Azzouz et al.
NEUROREPORT (2004)
Neuroprotection in Parkinson disease - Mysteries, myths, and misconceptions
AHV Schapira et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)
Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector
B Georgievska et al.
HUMAN GENE THERAPY (2004)
Derivation of midbrain dopamine neurons from human embryonic stem cells
AL Perrier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson's disease
C Lo Bianco et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time-and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system
B Georgievska et al.
JOURNAL OF NEUROSCIENCE (2004)
Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease
C Lo Bianco et al.
NEUROBIOLOGY OF DISEASE (2004)
Evaluation of animal models of Parkinson's disease for neuroprotective strategies
ME Emborg
JOURNAL OF NEUROSCIENCE METHODS (2004)
The differentiation potential of human foetal neuronal progenitor cells in vitro
SS Riaz et al.
DEVELOPMENTAL BRAIN RESEARCH (2004)
Stages in the development of Parkinson's disease-related pathology
H Braak et al.
CELL AND TISSUE RESEARCH (2004)
Midbrain-derived neural stem cells: from basic science to therapeutic approaches
A Storch et al.
CELL AND TISSUE RESEARCH (2004)
Dopaminergic differentiation of human embryonic stem cells
XM Zeng et al.
STEM CELLS (2004)
Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture
TC Schulz et al.
STEM CELLS (2004)
Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats
T Ben-Hur et al.
STEM CELLS (2004)
Isolation and characterization of neural progenitor cells from post-mortem human cortex
PH Schwartz et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)
A Eslamboli et al.
EXPERIMENTAL NEUROLOGY (2003)
Directed neuronal differentiation of human embryonic stem cells
TC Schulz et al.
BMC NEUROSCIENCE (2003)
Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells
A Storch et al.
JOURNAL OF CHEMICAL NEUROANATOMY (2003)
Novel functions and signalling pathways for GDNF
H Sariola et al.
JOURNAL OF CELL SCIENCE (2003)
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
CW Olanow et al.
ANNALS OF NEUROLOGY (2003)
Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue:: a role for protease activation
M Emgård et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue
V Cochen et al.
MOVEMENT DISORDERS (2003)
Gene expression in human neural stem cells: effects of leukemia inhibitory factor
LS Wright et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Intraputamenal infusion of GDNF in aged rhesus monkeys: Distribution and dopaminergic effects
Y Ai et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2003)
Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
H Braak et al.
JOURNAL OF NEURAL TRANSMISSION (2003)
Glial cell line-derived neurotrophic factor-supplemented hibernation of fetal ventral mesencephalic neurons for transplantation in Parkinson disease: long-term storage
AO Hebb et al.
JOURNAL OF NEUROSURGERY (2003)
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
SS Gill et al.
NATURE MEDICINE (2003)
Staging of brain pathology related to sporadic Parkinson's disease
H Braak et al.
NEUROBIOLOGY OF AGING (2003)
Comparative study of GDNF delivery systems for the CNS:: polymer rods, encapsulated cells, and lentiviral vectors
JC Bensadoun et al.
JOURNAL OF CONTROLLED RELEASE (2003)
Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
JG Nutt et al.
NEUROLOGY (2003)
Designing neuroprotection trials in Parkinson's disease
K Kieburtz
ANNALS OF NEUROLOGY (2003)
In vivo gene delivery of glial cell line-derived neurotrophic factor for Parkinson's disease
JH Kordower
ANNALS OF NEUROLOGY (2003)
Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons
J Ourednik et al.
NATURE BIOTECHNOLOGY (2002)
Dyskinesia after fetal cell transplantation for parkinsonism: A PET study
YL Ma et al.
ANNALS OF NEUROLOGY (2002)
Subthalamic GAD gene therapy in a Parkinson's disease rat model
J Luo et al.
SCIENCE (2002)
Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys
R Grondin et al.
BRAIN (2002)
Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer
B Georgievska et al.
EXPERIMENTAL NEUROLOGY (2002)
Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons
T Ostenfeld et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2002)
Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys
N Maswood et al.
NEUROBIOLOGY OF AGING (2002)
Gene transfer of a chimeric trans-activator is immunogenic and results in short-lived transgene expression
M Latta-Mahieu et al.
HUMAN GENE THERAPY (2002)
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
C Lo Bianco et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
JH Kim et al.
NATURE (2002)
The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon into dopaminergic neurons in vitro
SS Riaz et al.
DEVELOPMENTAL BRAIN RESEARCH (2002)
Global gene and cell replacement strategies via stem cells
KI Park et al.
GENE THERAPY (2002)
The GDNF family: Signalling, biological functions and therapeutic value
MS Airaksinen et al.
NATURE REVIEWS NEUROSCIENCE (2002)
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer
D Kirik et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Regional specification of rodent and human neurospheres
T Ostenfeld et al.
DEVELOPMENTAL BRAIN RESEARCH (2002)
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
LM Björklund et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes
SI Muramatsu et al.
HUMAN GENE THERAPY (2002)
Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: Feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
TJ Collier et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2002)
Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector
B Georgievska et al.
NEUROREPORT (2002)
Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease
L Wang et al.
GENE THERAPY (2002)
Characterisation of cell damage and death in embryonic mesencephalic tissue: A study on ultrastructure, vital stains and protease activity
M Emgard et al.
NEUROSCIENCE (2002)
Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study - Report of three cases
I Mendez et al.
JOURNAL OF NEUROSURGERY (2002)
In vitro differentiation of transplantable neural precursors from human embryonic stem cells
SC Zhang et al.
NATURE BIOTECHNOLOGY (2001)
Neural progenitors from human embryonic stem cells
BE Reubinoff et al.
NATURE BIOTECHNOLOGY (2001)
Induced neuronal differentiation of human embryonic stem cells
M Schuldiner et al.
BRAIN RESEARCH (2001)
Segregation of human neural stem cells in the developing primate forebrain
V Ourednik et al.
SCIENCE (2001)
In vitro generation and transplantation of precursor-derived human dopamine neurons
R Sánchez-Pernaute et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2001)
Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
A Storch et al.
EXPERIMENTAL NEUROLOGY (2001)
Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease
T Nakamura et al.
ANNALS OF NEUROLOGY (2001)
Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons
K Sawamoto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Cell culture - Progenitor cells from human brain after death
TD Palmer et al.
NATURE (2001)
Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
CR Freed et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Quantitative analysis of transgene protein, mRNA, and vector DNA following injection of an adenoviral vector harboring glial cell line-derived neurotrophic factor into the primate caudate nucleus
DA Kozlowski et al.
MOLECULAR THERAPY (2001)
Towards a neuroprotective gene therapy for Parkinson's disease:: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
A Björklund et al.
BRAIN RESEARCH (2000)
Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections
DA Kozlowski et al.
EXPERIMENTAL NEUROLOGY (2000)
Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
D Kirik et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2000)
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
JH Kordower et al.
SCIENCE (2000)
Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease
P Brundin et al.
BRAIN (2000)
Lentiviral vectors as a gene delivery system in the mouse midbrain:: Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF
JC Bensadoun et al.
EXPERIMENTAL NEUROLOGY (2000)
Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation
T Ostenfeld et al.
EXPERIMENTAL NEUROLOGY (2000)
Mesencephalic neural stem (progenitor) cells develop to dopaminergic neurons more strongly in dopamine-depleted striatum than in intact striatum
H Nishino et al.
EXPERIMENTAL NEUROLOGY (2000)
Convection-enhanced delivery of AAV vector in parkinsonian monkeys;: In vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach
KS Bankiewicz et al.
EXPERIMENTAL NEUROLOGY (2000)
Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
SH Lee et al.
NATURE BIOTECHNOLOGY (2000)
Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease - Report of two cases and technical considerations
I Mendez et al.
JOURNAL OF NEUROSURGERY (2000)
In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
C Rosenblad et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2000)
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease
N Deglon et al.
HUMAN GENE THERAPY (2000)
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