期刊
MOUNT SINAI JOURNAL OF MEDICINE
卷 75, 期 3, 页码 226-247出版社
WILEY-BLACKWELL
DOI: 10.1002/msj.20042
关键词
antidepressant; bipolar disorder; depression; glutamate; mania; plasticity; treatment
资金
- National Institute of Mental Heath
- Stanley Medical Research Institute
- National Alliance for Research on Schizophrenia And Depression
Current pharmacotherapy for bipolar disorder is generally unsatisfactory for a large number of patients. Even With adequate modern bipolar pharmacological therapies, many afflicted individuals continue to have persistent mood episode relapses, residual symptoms, functional impairment, and psychosocial disability. Creating novel therapeutics for bipolar disorder is urgently needed. Promising drug targets and compouunds for bipolar disorder worthy of further study include both systems and intracellular pathways and targets. Specifically, the purinergic system, the dynorphin Opioid neuropeptide system, the cholinergic system (muscarinic and nicotinic system), the melatonin and serotonin [5-hydroxytryptamine receptor 2C] system, the glutamatergic system; and the hypothalmic-pituitary adrenal axis have all been implicated. Intracelluar pathways and targets worthy of further study include glycogen synthase kinase-3 protein, protein kinase C, and the arachidonic acid cascade.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据