期刊
SEMINARS IN NEPHROLOGY
卷 35, 期 3, 页码 266-278出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semnephrol.2015.04.006
关键词
Digital pathology; whole slide imaging; virtual slide; virtual microscopy; NEPTUNE; renal pathology; glomerulus
资金
- Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research
- Nephrotic Syndrome Study Network Consortium (NEPTUNE), National Institutes of Health Rare Disease Clinical Research Network [U54-DK-083912]
- Office of Rare Diseases Research
- National Center for Advancing Translational Science
- National Institute of Diabetes and Digestive and Kidney Diseases
Conventional light microscopy has been used to characterize and classify renal diseases, evaluate histopathology in studies and trials, and educate renal pathologists and nephrologists. The advent of digital pathology, in which a glass slide can be scanned to create whole slide images (WSIs) for viewing and manipulating on a computer monitor, provides real and potential advantages compared with conventional light microscopy. Software tools such as annotation, morphometry, and image analysis can be applied to WSIs for studies or educational purposes, and the digital images are available globally to clinicians, pathologists, and investigators. New ways of assessing renal pathology with observational data collection may allow better morphologic correlations and integration with molecular and genetic signatures, refinements of classification schema, and understanding of disease pathogenesis. In multicenter studies, WSIs, which require additional quality assurance steps, provide efficiency by reducing slide shipping and consensus conference costs, and they allow slide viewing anytime and anywhere. Although validation studies for the routine diagnostic use of digital pathology still are needed, this is a powerful tool currently available for translational research, clinical trials, and education in renal pathology. (C) 2015 Elsevier Inc. All rights reserved.
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