期刊
SEMINARS IN IMMUNOLOGY
卷 27, 期 1, 页码 19-25出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2015.01.001
关键词
gamma delta T cells; T cell development; Pro-inflammatory cytokines
类别
资金
- European Research Council [StG_260352]
- CRUK
- Wellcome Trust
- Cancer Research UK [19309] Funding Source: researchfish
- The Francis Crick Institute [10093] Funding Source: researchfish
- Wellcome Trust [106292/Z/14/Z] Funding Source: researchfish
- Wellcome Trust [106292/Z/14/Z] Funding Source: Wellcome Trust
gamma delta T cells are major providers of the pro-inflammatory cytokines interferon-gamma (IFN gamma) and interleukin-17 (IL-17)in protective or pathogenic immune responses. Notably, murine gamma delta T cells commit to either IFN gamma or IL-17 production during development in the thymus, before any subsequent activation in the periphery. Here we discuss the molecular networks that underlie thymic gamma delta T cell differentiation, as well as the mechanisms that sustain or modify their functional properties in the periphery. We concentrate on recent findings on lymphoid and tissue-resident gamma delta T cell subpopulations, with an emphasis on genome-wide studies and their added value to elucidate the regulation of gamma delta T cell differentiation at the transcriptional and epigenetic (chromatin) levels. (C) 2015 Elsevier Ltd. All rights reserved.
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