期刊
SEMINARS IN FETAL & NEONATAL MEDICINE
卷 20, 期 1, 页码 47-51出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2014.12.004
关键词
Bilirubin-induced neurologic dysfunction (BIND); Cerebellum; Magnetic resonance imaging; Bilirubin; Subtle kernicterus
类别
资金
- Mario Lemieux Foundation
- Children's Hospital of Pittsburgh Foundation - Ian Harrison Family Fund for Neonatal Neurology Research Program
- National Institutes of Health [K23NS063371]
- Twenty-Five Club of Magee-Womens Hospital
Investigators have hypothesized a range of subcortical neuropathology in the genesis of bilirubin-induced neurologic dysfunction (BIND). The current review builds on this speculation with a specific focus on the cerebellum and its connections in the development of the subtle neuromotor disabilities of BIND. The focus on the cerebellum derives from the following observations: (i) the cerebellum is vulnerable to bilirubin-induced injury; perhaps the most vulnerable 'region within the central nervous system; (ii) infants with cerebellar injury exhibit a neuromotor phenotype similar to BIND; and (iii) the cerebellum has extensive bidirectional circuitry projections to motor and non-motor regions of the brainstem and cerebral cortex that impact a variety of neurobehaviors. Future study using advanced magnetic resonance neuroimaging techniques have the potential to shed new insights into bilirubin's effect on neural network topology via both structural and functional brain connectivity measurements. (C) 2014 Elsevier Ltd. All rights reserved.
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