期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 40, 期 -, 页码 8-16出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.02.012
关键词
Extracellular vesicle; Exosome; Microvesicle; Posttranslational modification; Oxidation; Citrullination
资金
- OTKA [PD104369, NK 84043]
- Marie Curie Networks for Initial Training-ITN-FP7-PEOPLE-ITN [PITN-GA-2011-289033]
- ME-HAD (COST Action) [BM1202]
Extracellular vesicles including exosomes, microvesicles and apoptotic vesicles, are phospholipid bilayer surrounded structures secreted by cells universally, in an evolutionarily conserved fashion. Posttranslational modifications such as oxidation, citrullination, phosphorylation and glycosylation play diverse roles in extracellular vesicle biology. Posttranslational modifications orchestrate the biogenesis of extracellular vesicles. The signals extracellular vesicles transmit between cells also often function via modulating posttranslational modifications of target molecules, given that extracellular vesicles are carriers of several active enzymes catalysing posttranslational modifications. Posttranslational modifications of extracellular vesicles can also contribute to disease pathology by e.g. amplifying inflammation, generating neoepitopes or carrying neoepitopes themselves. (C) 2015 Elsevier Ltd. All rights reserved.
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