期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 41, 期 -, 页码 49-58出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.04.020
关键词
Dendritic cells; Tissue-resident dendritic cells; Tolerogenic dendritic cells; Autoimmunity
资金
- National Institutes of Health [K01AR059378]
- Alliance for Lupus Research
A key function of dendritic cells (DCs) is to induce either immune tolerance or immune activation. Many new DC subsets are being recognized, and it is now clear that each DC subset has a specialized function. For example, different DC subsets may express different cell surface molecules and respond differently to activation by secretion of a unique cytokine profile. Apart from intrinsic differences among DC subsets, various immune modulators in the microenvironment may influence DC function; inappropriate DC function is closely related to the development of immune disorders. The most exciting recent advance in DC biology is appreciation of human DC subsets. In this review, we discuss functionally different mouse and human DC subsets both in lymphoid organs and non-lymphoid organs, the molecules that regulate DC function, and the emerging understanding of the contribution of DCs to autoimmune diseases. (C) 2014 Published by Elsevier Ltd.
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