期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 39, 期 -, 页码 106-114出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2014.03.035
关键词
TNF; RIG-I; TLR; NOD; IAP
资金
- Methusalem grant [BOF09/01M00709]
- European grants (Euregional PACT II)
- Belgian grants (Interuniversity Attraction Poles) [IAP 7/32]
- Flemish grants (Research Foundation Flanders) [FWO G.0875.11, FWO G.0973.11, FWO G.0A45.12N, FWO G.0172.12N, FWO G0787.13N]
- Ghent University grants (MRP)
- VIB
As indicated by their name, members of the Inhibitor of APoptosis (IAP) family were first believed to be functionally restricted to apoptosis inhibition. It is now clear that IAPs have a much wider spectrum of action, and recent studies even suggest that some of its members primarily regulate inflammatory responses. Inflammation, the first response of the immune system to infection or tissue injury, is highly regulated by ubiquitylation - a posttranslational modification of proteins with various consequences. In this review, we focus on the recently reported functions of XIAP, cIAP1 and cIAP2 as ubiquitin ligases regulating innate immunity and inflammation. (C) 2014 Elsevier Ltd. All rights reserved.
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