期刊
SEMINARS IN CANCER BIOLOGY
卷 31, 期 -, 页码 84-88出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2014.05.002
关键词
Apoptosis; Cell death; Cancer; Death receptor; Mitochondria
类别
资金
- Deutsche Forschungsgemeinschaft
- Ministerium fur Bildung und Forschung [01GM1104C]
- IUAP
- LOEWE
- Deutsche Krebshilfe
- Wilhelm-Sander-Stiftung
- Else Kroner Fresenius-Stiftung
- Jose Carreras Stiftung
Programmed cell death via apoptosis is characteristically disturbed in human cancers. This facilitates not only tumor formation and progression, but also treatment resistance. Since many currently applied anticancer treatment strategies rely on intact cell death signaling pathways for their therapeutic efficacy, a better understanding of the regulatory mechanisms that control cell death signaling pathways is critical to bypass resistance. Thus, reactivation of cell death programs in cancer cells may open new perspectives for more effective and more tumor-selective, yet less toxic anticancer therapies. (C) 2014 Elsevier Ltd. All rights reserved.
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