期刊
SEMINARS IN CANCER BIOLOGY
卷 32, 期 -, 页码 3-9出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2014.02.001
关键词
Oncogenes; Tumoral reprogramming; Stem cells; Cancer stem cell; Mouse model
类别
资金
- FEDER
- MICINN [SAF2012-32810]
- MEC OncoBIO Consolider-Ingenio [CSD2007-0017]
- NIH grant [R01 CA109335-04A1]
- ARIMMORA Project (FP7-ENV, European Union Seventh Framework Program)
- Junta de Castilla y Leon [BIO/SA06/13]
- proyecto en red de investigacion en celulas madre tumorales - Obra Social Kutxa y Conserjeria de Sanidad de la Junta de Castilla y Leon
- FSE-Conserjeria de Educacion de la Junta de Castilla y Leon [CSI020-12]
Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumor cells. However, recent evidences have revealed that cancer stem cells could arise through a tumor stem cell reprogramming mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of cancer development and proposes new approaches to treat cancer in the future. (C) 2014 Elsevier Ltd. All rights reserved.
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