期刊
MONATSHEFTE FUR CHEMIE
卷 144, 期 4, 页码 539-552出版社
SPRINGER WIEN
DOI: 10.1007/s00706-013-0947-1
关键词
Catalysis; Heterocycles; C-H activation; Metal carbonyls; Arylation; Detrifluoromethylation
资金
- Austrian Science Foundation (FWF) [P21202-N17]
A Ru-catalyzed mono-arylation in alpha-position of saturated cyclic amines is reported employing a C-H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to avoid bis-arylation. This highly selective transformation can be performed with different amines and arylboronate esters. Additionally, the directing group can be cleaved, taking advantage of an unprecedented detrifluoromethylation reaction.
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