Eco-friendly synthesis of highly substituted functionalized oxazines by FeCl3/SiO2 nanoparticles

An efficient and modern method for the preparation of amidoalkyl naphthols in the presence of silica nanoparticle-supported ferric chloride under thermal solvent-free conditions is explained. The prepared amidoalkyl naphthols were converted to 1,3-oxazines by Vilsmeier reagent in the presence of FeCl3/SiO2 nanoparticles. This method provides a novel route to synthesis amidoalkyl naphthol and 1,3-oxazine derivatives in terms of good yields, short reaction times, and recyclable catalyst.