期刊
MONATSHEFTE FUR CHEMIE
卷 143, 期 6, 页码 939-945出版社
SPRINGER WIEN
DOI: 10.1007/s00706-011-0671-7
关键词
Heterocycle; Piperidine; Multicomponent reaction; Homogeneous catalyst; p-TsOH center dot H2O
资金
- Research Council of the University of Sistan and Baluchestan
p-Toluenesulfonic acid monohydrate (p-TsOH center dot H2O) is a highly effective and efficient catalyst for the one-pot multicomponent coupling of aldehydes, amines, and beta-ketoesters in EtOH at ambient temperature to give highly functionalized piperidines in high yields. This one-pot reaction has some important advantages such as the easy workup procedure, simple and readily available precursors, nontoxic and inexpensive catalyst, and good to high yields.
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