期刊
MONATSHEFTE FUR CHEMIE
卷 142, 期 5, 页码 539-545出版社
SPRINGER WIEN
DOI: 10.1007/s00706-011-0456-z
关键词
Ethyl thiophene-3-carboxylate; Thienopyrimidines; Thienopyridines; Tetrazole derivatives; Pyrazole derivatives; Antimicrobial activity
The key intermediate ethyl 2-amino-5-benzoyl-4-methylthiophene-3-carboxylate was prepared by a Gewald reaction starting from benzoylacetone, sulfur, and ethyl cyanoacetate in the presence of diethylamine. This intermediate reacted with various reagents to afford different fused and polyfunctional substituted thiophenes. Antimicrobial screening of the synthesized compounds exhibited promising antimicrobial activities.
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