期刊
MONATSHEFTE FUR CHEMIE
卷 140, 期 6, 页码 619-623出版社
SPRINGER WIEN
DOI: 10.1007/s00706-008-0105-3
关键词
Imatinib; Arylamine; Carboxylic acid; Amidation; Reduction
A classical convergent approach for the synthesis of the anticancer drug imatinib has been substantially improved. Imatinib was assembled by coupling the amine and carboxylic acid precursors by using N, N'-carbonyldi-imidazole (CDI) as a condensing agent. Both intermediates have been synthesized by novel efficient methods.
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