期刊
MOLECULES AND CELLS
卷 33, 期 4, 页码 401-406出版社
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.1007/s10059-012-0009-2
关键词
gene expression; LAT; osteoclast; RANKL; transmembrane adaptor
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology (MEST) [2011-0013512]
- Korean Science and Engineering Foundation (KOSEF) National Research Laboratory
- Korean government (MEST) [R0A-2007-000-20025-0]
- National Research Foundation of Korea [2011-0013512, R0A-2007-000-20025-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
RANKL induces the formation of osteoclasts, which are responsible for bone resorption. Herein we investigate the role of the transmembrane adaptor proteins in RANKL-induced osteoclastogenesis. LAT positively regulates osteoclast differentiation and is up-regulated by RANKL via c-Fos and NFATc1, whereas LAB and LIME act as negative modulators of osteoclastogenesis. In addition, silencing of LAT by RNA interference or overexpression of a LAT dominant negative in bone marrow-derived macrophage cells attenuates RANKL-induced osteoclast formation. Furthermore, LAT is involved in RANKL-induced PLC gamma activation and NFATc1 induction. Thus, our data suggest that LAT acts as a positive regulator of RANKL-induced osteoclastogenesis.
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