期刊
MOLECULES AND CELLS
卷 27, 期 4, 页码 481-490出版社
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.1007/s10059-009-0054-7
关键词
Arabidopsis; demethylase; epigenetics; histone demethylation; Jumonji
资金
- Ministry of Education, Science and Technology/Korea Science and Engineering Foundation to the Environmental Biotechnology National Core Research Center [R15-2003-012-01001-0]
- Korea Research Foundation [KRF-2007313-C00703, KRF-2006-312-C00672]
- National Research Foundation of Korea [2006-312-C00672] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Diverse posttranslational modifications of histones, such as acetylation and methylation, play important roles in controlling gene expression. Histone methylation in particular is involved in a broad range of biological processes, including heterochromatin formation, X-chromosome inactivation, genomic imprinting, and transcriptional regulation. Recently, it has been demonstrated that proteins containing the Jumonji (Jmj) C domain can demethylate histones. In Arabidopsis, twenty-one genes encode JmjC domain-containing proteins, which can be clustered into five clades. To address the biological roles of the Arabidopsis genes encoding JmjC-domain proteins, we analyzed the temporal and spatial expression patterns of nine genes. RT-PCR analyses indicate all nine Arabidopsis thaliana Jmj (AtJmj) genes studied are actively expressed in various tissues. Furthermore, studies of transgenic plants harboring AtJmj::beta-glucuronidase fusion constructs reveal that these nine AtJmj genes are expressed in a developmentally and spatially regulated manner.
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