期刊
MOLECULES
卷 23, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules23081982
关键词
Arthrinium sp.; chromone; polyketide; antioxidant activity
资金
- National Natural Science Foundation of China [41506148, 31501104]
- Natural Science Foundation of Shandong Province [BS2015HZ005, JQ201721]
- Young Taishan Scholars Program [tsqn20161037]
- Open Fund of Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education [rdyw2018004]
- Program for Innovative Research Team in University [IRT-16R19]
- Project of Shandong Province Higher Educational Science and Technology Program [J18KA255]
- Shandong Talents Team Cultivation Plan of University Preponderant Discipline [10027]
Five new chromone derivatives, arthones A-E (1-5), together with eight known biogenetically related cometabolites (6-13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of 1 and 5 were established by electronic circular dichroism (ECD) calculations and that of 2 was determined by modified Mosher ester method. Compounds 3 and 8 exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC50 values ranging from 16.9 to 18.7 mu M. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 mu M.
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