期刊
MOLECULES
卷 23, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/molecules23092229
关键词
near infrared dye; fluorescence; supramolecular recognition; non-covalent; host guest; synthesis; quantum yield; multiplex imaging
资金
- University of Notre Dame
- NSF [CHE1708240]
- NIH [R01GM059078]
A new family of fluorescent thiophene and thienothiophene-containing squaraine dyes is described with tunable wavelengths that cover the absorption/emission range of 600-800 nm. The deep-red and near-infrared fluorescent compounds were easily prepared by simple synthesis and purification methods. Spectral studies showed that each squaraine was rapidly encapsulated by a tetralactam macrocycle, with nanomolar affinity in water, to produce a threaded supramolecular complex with high chemical stability, increased fluorescence quantum yield, and decreased fluorescence quenching upon dye self-aggregation. Energy transfer within the supramolecular complex permitted multiplex emission. That is, two separate dyes with fluorescence emission bands that match the popular Cy5 and Cy7 channels, could be simultaneously excited with a beam of 375 nm light. A broad range of practical applications is envisioned in healthcare diagnostics, microscopy, molecular imaging, and fluorescence-guided surgery.
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