期刊
MOLECULES
卷 19, 期 9, 页码 14902-14918出版社
MDPI
DOI: 10.3390/molecules190914902
关键词
oxidative stress; redox cycling; NQO1; Nrf2; epidermal growth factor receptor; protein tyrosine phosphatases (PTP); gap junction; connexin
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN 402228-2011]
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings.
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