期刊
MOLECULES
卷 19, 期 7, 页码 9257-9272出版社
MDPI
DOI: 10.3390/molecules19079257
关键词
Baccharis dracunculifolia; Brazilian green propolis; acetaminophen; carbon tetrachloride; hepatoprotective
资金
- CNPq [Proc. 487221/2012-5]
- FAPEMIG [Proc. APQ 00171/11]
- PIBIC/CNPq/UFJF
- CAPES
- CNPq
In this work we investigated the in vivo protective effects of Baccharis dracunculifolia leaves extract (BdE) against carbon tetrachloride (CCl4)- and acetaminophen (APAP)-induced hepatotoxicity. Total phenolic content, total flavonoid content, antioxidant DPPH radical scavenging activity, and HPLC analysis were performed. Our results showed that pretreatment with BdE significantly reduced the damage caused by CCl4 and APAP on the serum markers of hepatic injury, AST, ALT, and ALP. Results were confirmed by histopathological analysis. Phytochemical analysis, performed by HPLC, showed that BdE was rich in p-coumaric acid derivatives, caffeoylquinic acids and flavonoids. BdE also showed DPPH antioxidant activity (EC50 of 15.75 +/- 0.43 mu g/mL), and high total phenolic (142.90 +/- 0.77 mg GAE/g) and flavonoid (51.47 +/- 0.60 mg RE/g) contents. This study indicated that B. dracunculifolia leaves extract has relevant in vivo hepatoprotective properties.
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