期刊
MOLECULES
卷 19, 期 10, 页码 16959-16975出版社
MDPI
DOI: 10.3390/molecules191016959
关键词
Ferula lutea; secondary metabolites; phenolic; antioxidant; anti-inflammatory; cytotoxic
A phytochemical investigation of the Ferula lutea (Poir.) Maire flowers has led to the isolation of a new compound, (E)-5-ethylidenefuran-2(5H)-one-5-O-beta-D-glucopyranoside (1), designated ferunide, 4-hydroxy-3-methylbut-2-enoic acid (2), reported for the first time as a natural product, together with nine known compounds, verbenone-5-O-beta-D-glucopyranoside (3), 5-O-caffeoylquinic acid (4), methyl caffeate (5), methyl 3,5-O-dicaffeoylquinate (6), 3,5-O-dicaffeoylquinic acid (7), isorhamnetin-3-O-alpha-L-rhamnopyranosyl(1 -> 6)-beta-Dglucopyranoside, narcissin (8), (-)-marmesin (9), isoimperatorin (10) and 2,3,6-trimethylbenzaldehyde (11). Compounds 3-10 were identified for the first time in Ferula genus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR experiments, mass spectroscopy and X-ray diffraction analysis (compound 2), as well as by comparison with literature data. The antioxidant, anti-inflammatory and cytotoxic activities of isolated compounds were evaluated. Results showed that compound 7 exhibited the highest antioxidant activity with IC50 values of 18 +/- 0.5 mu mol/L and 19.7 +/- 0.7 mu mol/L by DPPH radical and ABTS radical cation, respectively. The compound 6 exhibited the highest anti-inflammatory activity with an IC50 value of 5.3 +/- 0.1 mu mol/L against 5-lipoxygenase. In addition, compound 5 was found to be the most cytotoxic, with IC50 values of 22.5 +/- 2.4 mu mol/L, 17.8 +/- 1.1 mu mol/L and 25 +/- 1.1 mu mol/L against the HCT-116, IGROV-1 and OVCAR-3 cell lines, respectively.
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