期刊
MOLECULES
卷 19, 期 2, 页码 1622-1634出版社
MDPI
DOI: 10.3390/molecules19021622
关键词
maghemite; nanoparticles; magnetic; platinum complexes; 7-azaindole derivatives; drug delivery
资金
- Czech Science Foundation [GACRP207/11/0841]
- Operational Program Research and Development for Innovations-European Regional Development Fund [CZ.1.05/2.1.00/03.0058]
- Operational Program Education for Competitiveness-European Social Fund of the Ministry of Education, Youth and Sports of the Czech Republic [CZ.1.07/2.3.00/20.0017]
- Palacky University in Olomouc [PrF_2013_015]
This study describes a one-pot synthesis of superparamagnetic maghemite-based 4-aminobenzoic acid-coated spherical core-shell nanoparticles (PABA@FeNPs) as suitable nanocomposites potentially usable as magnetic carriers for drug delivery. The PABA@FeNPs system was subsequently functionalized by the activated species (1* and 2*) of highly in vitro cytotoxic cis-[PtCl2(3Claza)(2)] (1; 3Claza stands for 3-chloro-7-azaindole) or cis-[PtCl2(5Braza)(2)] (2; 5Braza stands for 5-bromo-7-azaindole), which were prepared by a silver(I) ion assisted dechlorination of the parent dichlorido complexes. The products 1*@PABA@FeNPs and 2*@PABA@FeNPs, as well as an intermediate PABA@FeNPs, were characterized by a combination of various techniques, such as Mossbauer, FTIR and EDS spectroscopy, thermal analysis, SEM and TEM. The results showed that the products consist of well-dispersed maghemite-based nanoparticles of 13 nm average size that represent an easily obtainable system for delivery of highly cytotoxic cisplatin-like complexes in oncological practice.
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