期刊
MOLECULES
卷 19, 期 7, 页码 9089-9100出版社
MDPI
DOI: 10.3390/molecules19079089
关键词
cholesteryl-modification; glucomannan; Bletilla striata; hydrogel property
资金
- National Natural Science Foundation of China [81173559]
- Key Scientific Program of Jilin Province [YYZX201128]
- Jilin Province Key Laboratory on Chemistry and Biology of Natural Drugs in Changbai Mountain
A glucomannan-type polysaccharide, named BSP, was obtained from the tubers of Bletilla striata by ultrasonic-assisted extraction, ethanol precipitation, deproteination and gel-permeation chromatography. HPLC analysis revealed that BSP contained mannose and glucose in the molar ratio of 3.5:1. Its molecular weight (Mw) was estimated to be 20 kDa. Methylation analysis, FT-IR and NMR analyses indicated that BSP consisted of (1 -> 4)-linked beta-D-glucopyranosyl residues and (1 -> 4)-linked beta-D-mannopyranosyl residues. Cholesteryl succinate was linked to BSP to make it more amphiphilic and the degree of substitution of cholesteryl succinate-BSP was 3.2%. The critical micelle concentration of modified BSP was 0.001 mg/mL, suggesting it could self-assemble into nanoparticles in aqueous solution.
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